Discovery of 6-[(3S,4S)-4-Amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl]-3-(2,3-dichlorophenyl)-2-methyl-3,4-dihydropyrimidin-4-one (IACS-15414), a Potent and Orally Bioavailable SHP2 Inhibitor

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journal：Journal of Medicinal Chemistry

Authors：Barbara Czako; Yuting Sun; Timothy McAfoos; Jason B. Cross; Paul G. Leonard; Jason P. Burke; Christopher L. Carroll; Ningping Feng; Angela L. Harris; Yongying Jiang; Zhijun Kang; Jeffrey J. Kovacs; Pijus Mandal; Brooke A. Meyers; Faika Mseeh; Connor A. Parker; Simon S. Yu; Christopher C. Williams; Qi Wu; Maria Emilia Di Francesco; Giulio Draetta; Timothy Heffernan; Joseph. R. Marszalek; Nancy E. Kohl; Philip Jones

Published date：2021-10-28

DOI：10.1021/acs.jmedchem.1c01132

PDF link：https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c01132

Article link：http://dx.doi.org/10.1021/acs.jmedchem.1c01132

Article Source：American Chemical Society (ACS)。

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[ACS] Discovery of 6-[(3S,4S)-4-Amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl]-3-(2,3-dichlorophenyl)-2-methyl-3,4-dihydropyrimidin-4-one (IACS-15414), a Potent and Orally Bioavailable SHP2 Inhibitor

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[ACS] Discovery of 6-[(3S,4S)-4-Amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl]-3-(2,3-dichlorophenyl)-2-methyl-3,4-dihydropyrimidin-4-one (IACS-15414), a Potent and Orally Bioavailable SHP2 Inhibitor Copy

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[ACS] Discovery of 6-[(3S,4S)-4-Amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl]-3-(2,3-dichlorophenyl)-2-methyl-3,4-dihydropyrimidin-4-one (IACS-15414), a Potent and Orally Bioavailable SHP2 Inhibitor