X-ray Structure-Guided Discovery of a Potent Benzimidazole Glutaminyl Cyclase Inhibitor That Shows Activity in a Parkinson’s Disease Mouse Model

Post time 2024-6-4 15:01:38

journal：Journal of Medicinal Chemistry

Authors：Jun Mou; Xiang-Li Ning; Xin-Yue Wang; Shu-Yan Hou; Fan-Bo Meng; Cong Zhou; Jing-Wei Wu; Chunyan Li; Tao Jia; Xiaoai Wu; Yong Wu; Yongping Chen; Guo-Bo Li

Published date：--

DOI：10.1021/acs.jmedchem.4c00049

PDF link：https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.4c00049

Article link：http://dx.doi.org/10.1021/acs.jmedchem.4c00049

Article Source：American Chemical Society (ACS)。

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Post time 2024-6-4 15:01:39

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[ACS] X-ray Structure-Guided Discovery of a Potent Benzimidazole Glutaminyl Cyclase Inhibitor That Shows Activity in a Parkinson’s Disease Mouse Model

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[ACS] X-ray Structure-Guided Discovery of a Potent Benzimidazole Glutaminyl Cyclase Inhibitor That Shows Activity in a Parkinson’s Disease Mouse Model