Discovery of a Novel Orally Bioavailable FLT3-PROTAC Degrader for Efficient Treatment of Acute Myeloid Leukemia and Overcoming Resistance of FLT3 Inhibitors

Post time 2024-4-26 07:33:14

journal：Journal of Medicinal Chemistry

Authors：Junwei Wang; Quanjin Rong; Lei Ye; Bingqian Fang; Yifan Zhao; Yu Sun; Haikun Zhou; Dan Wang; Jinting He; Zhenzhen Cui; Qijian Zhang; Di Kang; Lihong Hu

Published date：--

DOI：10.1021/acs.jmedchem.4c00051

PDF link：https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.4c00051

Article link：http://dx.doi.org/10.1021/acs.jmedchem.4c00051

Article Source：American Chemical Society (ACS)。

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Post time 2024-4-26 07:33:15

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[ACS] Discovery of a Novel Orally Bioavailable FLT3-PROTAC Degrader for Efficient Treatment of Acute Myeloid Leukemia and Overcoming Resistance of FLT3 Inhibitors

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[ACS] Discovery of a Novel Orally Bioavailable FLT3-PROTAC Degrader for Efficient Treatment of Acute Myeloid Leukemia and Overcoming Resistance of FLT3 Inhibitors